Crossbow Therapeutics is seeking a highly motivated and detail-oriented Director specializing in immuno-oncology to join our Translational Medicine team in Cambridge, MA. This individual will provide scientific and strategic leadership for translational efforts for one or more programs guiding the advancement of Crossbow’s therapeutic pipeline toward clinical development. The ideal candidate will work closely with research, clinical, and development partners and will help to shape integrated development plans and contribute to clinical and scientific deliverables. If you are passionate about developing novel medicines, this role offers a dynamic opportunity to advance the development of innovative T-cell engager TCR-mimetic antibody-based therapies for patients with cancer. \n Key Responsibilities Develops and leads translational strategy and efforts for individual programs to help advance Crossbow’s therapeutic pipeline towards the clinic. Provides oversight of the development, validation, and execution of clinical biomarker and PK/PD assays with external CROs and actively manages vendor relationships. Drives clinical biomarker and PK/PD sample testing and data analysis in close collaboration with clinical and development operations line functions. Serves as the translational medicine lead representative to cross-functional program teams and drive integrated program development plans. Leads external collaborations and sponsored research agreements that enable translational efforts to help inform and advance our therapeutic pipeline. Authors translational medicine sections of IND modules, clinical protocols, and other clinical trial documents and technical reports. Leads internal biomarker assay development experiments and efforts at the bench to enable patient stratification, pharmacodynamic assessment, and clinical response prediction. Provides translational scientific and strategic input into novel target identification. Understands project timelines and deliverables, and plans/coordinates project work accordingly with departmental, functional, and other stakeholders. Qualifications MD, MD/PhD, or Ph.D. in Immunology, Molecular Biology, Cancer Biology, or other scientifically related field required Minimum 5 years of experience in industry with significant experience in translational science research, clinical biomarker assay development, and leading and advancing programs during IND-enabling phase through early phase clinical development. A strong background in immuno-oncology with experience in biologics and T cell engager antibody development is preferred. Experience across a broad number of analytical platforms including multiparameter FACS, multiplex immunoassay platforms, and bioanalytical assay development is highly desirable. Strong team player with the ability to work in cross-functional teams. Excellent interpersonal, verbal, and written communication skills. While some flexibility may be offered, the primary expectation is for on-site work at our Cambridge location on average 3 days per week. The Benefits of Working at Crossbow We offer a competitive compensation that includes an annual discretionary bonus and equity package, allowing you to have a stake in our long-term success. Base salary will be commensurate with experience and in the range of $190,000 – $240,000. Take care of your physical and mental health through our subsidized medical, dental and vision insurance programs. Enjoy work and life with our flexible paid time off program, annual holidays including a Winter Break and sick time. Utilize our tuition reimbursement program to further your education. Maximize your future retirement by participating in our 401k program which includes a 100% match on your first 4% contributed. \n About Crossbow Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer. Join us on our bold quest to broaden the benefits of immunotherapy and improve the lives of people living with cancer. For more information, visit us at Crossbow Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace where every individual is respected and valued. We recognize that diversity fuels innovation and enhances our capacity to achieve meaningful outcomes through our work. Note to Recruiters: Please be aware that we do not accept unsolicited resumes and kindly request that you do not contact our team regarding this job posting. If a resume is submitted to a Crossbow team member without a prior agreement, we will not be obligated to pay any referral or placement fees.
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